Drug interactions
Aripiprazole + Insulin glargine-lixisenatide
Severity: Minor
Aripiprazole and Insulin glargine-lixisenatide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole can alter glucose metabolism, and hyperglycemia or diabetes has been reported with atypical antipsychotics. It may reduce the effect of the antidiabetic regimen, although the metabolic risk is lower than with some other agents in the class.
What this interaction means in plain words
Aripiprazole and Insulin glargine-lixisenatide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Insulin glargine-lixisenatide belongs to Endocrine.
Why it happens
Pharmacodynamic opposition; antipsychotic-related changes in insulin sensitivity and glucose regulation.
What to do
Monitor fasting glucose and HbA1c after starting aripiprazole and titrate the insulin dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Insulin glargine-lixisenatide?
MediHelp rates the interaction as minor. Aripiprazole and Insulin glargine-lixisenatide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aripiprazole can alter glucose metabolism, and hyperglycemia or diabetes has been reported with atypical antipsychotics. It may reduce the effect of the antidiabetic regimen, although the metabolic risk is lower than with some other agents in the class.
How serious is the interaction between Aripiprazole and Insulin glargine-lixisenatide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting aripiprazole and titrate the insulin dose as needed.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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