Drug interactions
Aripiprazole + Isoflurane
Severity: Moderate
Aripiprazole and Isoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoflurane can lengthen the QTc interval and aripiprazole has a small potential effect as well. The combination during anesthesia adds modestly to arrhythmia risk, mainly in patients with other risk factors.
What this interaction means in plain words
Aripiprazole and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Isoflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effect on ventricular repolarization.
What to do
Review baseline ECG and correct electrolyte abnormalities before surgery. Monitor ECG during anesthesia and recovery in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Isoflurane
Frequently asked questions
Can I take Aripiprazole with Isoflurane?
MediHelp rates the interaction as moderate. Aripiprazole and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoflurane can lengthen the QTc interval and aripiprazole has a small potential effect as well. The combination during anesthesia adds modestly to arrhythmia risk, mainly in patients with other risk factors.
How serious is the interaction between Aripiprazole and Isoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review baseline ECG and correct electrolyte abnormalities before surgery. Monitor ECG during anesthesia and recovery in patients with other QT risk factors.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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