Drug interactions
Aripiprazole + Istradefylline
Severity: Minor
Aripiprazole and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At higher doses istradefylline weakly inhibits CYP3A4 and can raise levels of CYP3A4 substrates such as aripiprazole. The effect is likely modest and was not seen at the lower dose.
What this interaction means in plain words
Aripiprazole and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline at higher doses inhibits CYP3A4, reducing aripiprazole clearance.
What to do
Monitor for aripiprazole adverse effects such as akathisia and sedation if istradefylline 40 mg/day is used, and reduce the aripiprazole dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Aripiprazole with Istradefylline?
MediHelp rates the interaction as minor. Aripiprazole and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At higher doses istradefylline weakly inhibits CYP3A4 and can raise levels of CYP3A4 substrates such as aripiprazole. The effect is likely modest and was not seen at the lower dose.
How serious is the interaction between Aripiprazole and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for aripiprazole adverse effects such as akathisia and sedation if istradefylline 40 mg/day is used, and reduce the aripiprazole dose if they occur.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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