Drug interactions
Aripiprazole + Ivosidenib
Severity: Major
Aripiprazole and Ivosidenib: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower aripiprazole concentrations, reducing antipsychotic control. Ivosidenib also prolongs the QT interval, and aripiprazole may add a small additional effect.
What this interaction means in plain words
Aripiprazole and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aripiprazole belongs to Central Nervous System; Ivosidenib belongs to Oncology.
Why it happens
CYP3A4 induction by ivosidenib increases aripiprazole clearance, together with additive QT prolongation.
What to do
Monitor for loss of psychiatric response and consider increasing the aripiprazole dose. Monitor ECG and electrolytes during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Abilify 1 mg/mL Oral Solution - SmPC sections 4.3/4.5 (class statement: medicinal products known to cause QT prolongation; "If aripiprazole is administered concomitantly with medicinal products known to cause QT prolongation or electrolyte imbalance, caution should be used.") — electronic medicines compendium (UK SmPC)
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Aripiprazole with Ivosidenib?
MediHelp rates the interaction as major. Aripiprazole and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ivosidenib induces CYP3A4 and may lower aripiprazole concentrations, reducing antipsychotic control. Ivosidenib also prolongs the QT interval, and aripiprazole may add a small additional effect.
How serious is the interaction between Aripiprazole and Ivosidenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of psychiatric response and consider increasing the aripiprazole dose. Monitor ECG and electrolytes during treatment.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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