Drug interactions
Aripiprazole + Larotrectinib
Severity: Minor
Aripiprazole and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate with some in vitro inhibitory potential, and an increase in aripiprazole exposure is possible but not well characterized clinically.
What this interaction means in plain words
Aripiprazole and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Larotrectinib belongs to Oncology.
Why it happens
Possible weak inhibition of CYP3A4 by larotrectinib; the clinical effect is not well established.
What to do
No routine dose change is needed. Monitor for aripiprazole adverse effects such as akathisia and sedation after larotrectinib is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Aripiprazole with Larotrectinib?
MediHelp rates the interaction as minor. Aripiprazole and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate with some in vitro inhibitory potential, and an increase in aripiprazole exposure is possible but not well characterized clinically.
How serious is the interaction between Aripiprazole and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for aripiprazole adverse effects such as akathisia and sedation after larotrectinib is started.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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