Drug interactions
Aripiprazole + Lefamulin
Severity: Moderate
Aripiprazole and Lefamulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin can prolong the QT interval, and aripiprazole may add a minor effect. Lefamulin is also a CYP3A4 inhibitor, which could modestly raise aripiprazole exposure with oral lefamulin.
What this interaction means in plain words
Aripiprazole and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Lefamulin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation, with possible CYP3A4 inhibition by lefamulin.
What to do
Check a baseline ECG and correct electrolytes, and monitor QTc during the antibiotic course. Choose a non-QT-prolonging antibiotic if the patient has other arrhythmia risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Aripiprazole with Lefamulin?
MediHelp rates the interaction as moderate. Aripiprazole and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lefamulin can prolong the QT interval, and aripiprazole may add a minor effect. Lefamulin is also a CYP3A4 inhibitor, which could modestly raise aripiprazole exposure with oral lefamulin.
How serious is the interaction between Aripiprazole and Lefamulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and correct electrolytes, and monitor QTc during the antibiotic course. Choose a non-QT-prolonging antibiotic if the patient has other arrhythmia risk factors.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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