Drug interactions
Aripiprazole + Lofexidine
Severity: Moderate
Aripiprazole and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine causes sedation, hypotension, bradycardia and QT prolongation, and aripiprazole can add sedation and orthostasis. Combined use may increase the risk of drowsiness, low blood pressure and arrhythmia.
What this interaction means in plain words
Aripiprazole and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Lofexidine belongs to Central Nervous System.
Why it happens
Additive CNS depression, hypotension and effects on cardiac repolarization.
What to do
Monitor blood pressure, heart rate and ECG, and correct electrolyte disturbances. Warn the patient about sedation and orthostatic dizziness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Aripiprazole with Lofexidine?
MediHelp rates the interaction as moderate. Aripiprazole and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine causes sedation, hypotension, bradycardia and QT prolongation, and aripiprazole can add sedation and orthostasis. Combined use may increase the risk of drowsiness, low blood pressure and arrhythmia.
How serious is the interaction between Aripiprazole and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG, and correct electrolyte disturbances. Warn the patient about sedation and orthostatic dizziness.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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