Drug interactions
Aripiprazole + Metformin-repaglinide
Severity: Minor
Aripiprazole and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics can cause hyperglycemia and may worsen glycemic control in patients treated with metformin and repaglinide. Aripiprazole has a relatively low metabolic risk, but glucose changes are possible.
What this interaction means in plain words
Aripiprazole and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Metformin-repaglinide belongs to Endocrine.
Why it happens
Antipsychotic-related insulin resistance may oppose the effects of antidiabetic drugs.
What to do
Monitor fasting glucose and HbA1c after starting aripiprazole and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Metformin-repaglinide?
MediHelp rates the interaction as minor. Aripiprazole and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atypical antipsychotics can cause hyperglycemia and may worsen glycemic control in patients treated with metformin and repaglinide. Aripiprazole has a relatively low metabolic risk, but glucose changes are possible.
How serious is the interaction between Aripiprazole and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting aripiprazole and adjust antidiabetic therapy as needed.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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