Drug interactions
Aripiprazole + Methadone
Severity: Minor
Aripiprazole and Methadone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole has minimal QT effect at usual doses, so the arrhythmic risk with methadone is low. The more relevant concern is additive sedation, and methadone is not a significant CYP2D6 or 3A4 inhibitor of aripiprazole.
What this interaction means in plain words
Aripiprazole and Methadone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Methadone belongs to Musculoskeletal.
Why it happens
Possible weak additive QT and CNS depressant effects; no major pharmacokinetic mechanism is established.
What to do
Combination is generally acceptable; monitor for sedation and consider an ECG if other QT risk factors are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Methadone?
MediHelp rates the interaction as minor. Aripiprazole and Methadone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aripiprazole has minimal QT effect at usual doses, so the arrhythmic risk with methadone is low. The more relevant concern is additive sedation, and methadone is not a significant CYP2D6 or 3A4 inhibitor of aripiprazole.
How serious is the interaction between Aripiprazole and Methadone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Combination is generally acceptable; monitor for sedation and consider an ECG if other QT risk factors are present.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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