Drug interactions
Aripiprazole + Morphine
Severity: Moderate
Aripiprazole and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause sedation, dizziness and orthostatic hypotension, so combined use may increase CNS depression and the risk of falls.
What this interaction means in plain words
Aripiprazole and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Morphine belongs to Musculoskeletal.
Why it happens
Additive CNS depressant and hypotensive effects.
What to do
Start morphine at a low dose and titrate carefully, monitoring sedation and blood pressure, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Morphine?
MediHelp rates the interaction as moderate. Aripiprazole and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause sedation, dizziness and orthostatic hypotension, so combined use may increase CNS depression and the risk of falls.
How serious is the interaction between Aripiprazole and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start morphine at a low dose and titrate carefully, monitoring sedation and blood pressure, especially in older patients.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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