Drug interactions
Aripiprazole + Nifedipine
Severity: Minor
Aripiprazole and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine is a weak CYP3A4 inhibitor and may slightly increase aripiprazole exposure. Both drugs can also contribute to orthostatic hypotension.
What this interaction means in plain words
Aripiprazole and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Nifedipine belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition plus additive hypotensive effects.
What to do
No dose change is usually needed. Monitor for orthostatic hypotension and sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Nifedipine?
MediHelp rates the interaction as minor. Aripiprazole and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine is a weak CYP3A4 inhibitor and may slightly increase aripiprazole exposure. Both drugs can also contribute to orthostatic hypotension.
How serious is the interaction between Aripiprazole and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for orthostatic hypotension and sedation.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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