Drug interactions
Aripiprazole + Oxcarbazepine
Severity: Moderate
Aripiprazole and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine can lower aripiprazole exposure, potentially reducing its antipsychotic effect and risking relapse. The induction effect is weaker than that of carbamazepine.
What this interaction means in plain words
Aripiprazole and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 increases the metabolic clearance of aripiprazole.
What to do
Monitor clinical response and consider increasing the aripiprazole dose if efficacy declines. Reduce the dose again if oxcarbazepine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Aripiprazole with Oxcarbazepine?
MediHelp rates the interaction as moderate. Aripiprazole and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine can lower aripiprazole exposure, potentially reducing its antipsychotic effect and risking relapse. The induction effect is weaker than that of carbamazepine.
How serious is the interaction between Aripiprazole and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider increasing the aripiprazole dose if efficacy declines. Reduce the dose again if oxcarbazepine is stopped.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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