Drug interactions
Aripiprazole + Oxybutynin
Severity: Minor
Aripiprazole and Oxybutynin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole has mild anticholinergic activity, so adding it to oxybutynin may modestly add to constipation, dry mouth and urinary retention. Other effects suggested for this pair are not well supported.
What this interaction means in plain words
Aripiprazole and Oxybutynin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Oxybutynin belongs to Genitourinary.
Why it happens
Additive weak antimuscarinic effects; no established pharmacokinetic interaction.
What to do
Monitor for constipation, urinary retention and cognitive effects, especially in older patients. No dose change is routinely needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxybutynin
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Oxybutynin?
MediHelp rates the interaction as minor. Aripiprazole and Oxybutynin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aripiprazole has mild anticholinergic activity, so adding it to oxybutynin may modestly add to constipation, dry mouth and urinary retention. Other effects suggested for this pair are not well supported.
How serious is the interaction between Aripiprazole and Oxybutynin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for constipation, urinary retention and cognitive effects, especially in older patients. No dose change is routinely needed.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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