Drug interactions
Aripiprazole + Pasireotide
Severity: Moderate
Aripiprazole and Pasireotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide can prolong the QT interval and aripiprazole has low QT liability, so combined use may modestly add to risk, especially with bradycardia or electrolyte disturbances.
What this interaction means in plain words
Aripiprazole and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Pasireotide belongs to Endocrine.
Why it happens
Possible additive QT prolongation.
What to do
Obtain a baseline ECG and monitor it during therapy, and correct potassium and magnesium. Avoid adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Aripiprazole with Pasireotide?
MediHelp rates the interaction as moderate. Aripiprazole and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pasireotide can prolong the QT interval and aripiprazole has low QT liability, so combined use may modestly add to risk, especially with bradycardia or electrolyte disturbances.
How serious is the interaction between Aripiprazole and Pasireotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it during therapy, and correct potassium and magnesium. Avoid adding other QT-prolonging drugs.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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