Drug interactions
Aripiprazole + Pazopanib
Severity: Moderate
Aripiprazole and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib can prolong the QT interval and cause torsades de pointes. Aripiprazole adds a small additional effect, and pazopanib is a weak CYP3A4 inhibitor that may slightly raise aripiprazole levels.
What this interaction means in plain words
Aripiprazole and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Pazopanib belongs to Oncology.
Why it happens
Additive QTc prolongation, with minor CYP3A4 inhibition by pazopanib.
What to do
Check baseline and periodic ECG and correct electrolytes. Monitor for aripiprazole adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Aripiprazole with Pazopanib?
MediHelp rates the interaction as moderate. Aripiprazole and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib can prolong the QT interval and cause torsades de pointes. Aripiprazole adds a small additional effect, and pazopanib is a weak CYP3A4 inhibitor that may slightly raise aripiprazole levels.
How serious is the interaction between Aripiprazole and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline and periodic ECG and correct electrolytes. Monitor for aripiprazole adverse effects.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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