Drug interactions
Aripiprazole + Phenelzine
Severity: Moderate
Aripiprazole and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole combined with an MAOI may add to serotonergic activity, and rarely lead to serotonin syndrome or neuroleptic malignant syndrome. Additive hypotension and sedation may also occur.
What this interaction means in plain words
Aripiprazole and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Why it happens
Aripiprazole partial agonism at 5-HT1A receptors and dopamine modulation may add to the increased monoamine levels caused by MAO inhibition.
What to do
Monitor for agitation, tremor, clonus, hyperthermia and rigidity, particularly after dose increases. Use the lowest effective doses and stop one agent if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Phenelzine?
MediHelp rates the interaction as moderate. Aripiprazole and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aripiprazole combined with an MAOI may add to serotonergic activity, and rarely lead to serotonin syndrome or neuroleptic malignant syndrome. Additive hypotension and sedation may also occur.
How serious is the interaction between Aripiprazole and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, clonus, hyperthermia and rigidity, particularly after dose increases. Use the lowest effective doses and stop one agent if toxicity is suspected.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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