Drug interactions
Aripiprazole + Sorafenib
Severity: Moderate
Aripiprazole and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sorafenib can prolong the QT interval, and aripiprazole may add a small effect. The risk is greater with electrolyte disturbance or heart disease.
What this interaction means in plain words
Aripiprazole and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Sorafenib belongs to Oncology.
Why it happens
Additive pharmacodynamic effect on cardiac repolarization.
What to do
Check baseline ECG and electrolytes and repeat periodically. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Sorafenib
Frequently asked questions
Can I take Aripiprazole with Sorafenib?
MediHelp rates the interaction as moderate. Aripiprazole and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sorafenib can prolong the QT interval, and aripiprazole may add a small effect. The risk is greater with electrolyte disturbance or heart disease.
How serious is the interaction between Aripiprazole and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes and repeat periodically. Correct potassium and magnesium abnormalities.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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