Drug interactions
Aripiprazole + Tolterodine
Severity: Minor
Aripiprazole and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole has little antimuscarinic activity, so additive anticholinergic effects with tolterodine are small. No clinically important change in absorption of either drug is established. Constipation or dry mouth may occasionally be additive.
What this interaction means in plain words
Aripiprazole and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Tolterodine belongs to Genitourinary.
Why it happens
Weak additive antimuscarinic effects; no established pharmacokinetic interaction.
What to do
No dose adjustment needed. Monitor for constipation and urinary retention in susceptible patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Tolterodine?
MediHelp rates the interaction as minor. Aripiprazole and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aripiprazole has little antimuscarinic activity, so additive anticholinergic effects with tolterodine are small. No clinically important change in absorption of either drug is established. Constipation or dry mouth may occasionally be additive.
How serious is the interaction between Aripiprazole and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment needed. Monitor for constipation and urinary retention in susceptible patients.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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