Drug interactions
Aripiprazole + Triptorelin
Severity: Moderate
Aripiprazole and Triptorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptorelin, a GnRH agonist used for androgen deprivation, can prolong the QT interval because of testosterone suppression. Aripiprazole has a low but recognised potential for QT effects, so the combination may add modestly to arrhythmia risk, especially with other risk factors.
What this interaction means in plain words
Aripiprazole and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Triptorelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation, with androgen deprivation from triptorelin as a contributor.
What to do
Obtain a baseline ECG and correct hypokalemia and hypomagnesemia before starting. Repeat the ECG if other QT-prolonging drugs are added or if palpitations or syncope occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aripiprazole and Triptorelin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Triptorelin
Frequently asked questions
Can I take Aripiprazole with Triptorelin?
MediHelp rates the interaction as moderate. Aripiprazole and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triptorelin, a GnRH agonist used for androgen deprivation, can prolong the QT interval because of testosterone suppression. Aripiprazole has a low but recognised potential for QT effects, so the combination may add modestly to arrhythmia risk, especially with other risk factors.
How serious is the interaction between Aripiprazole and Triptorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct hypokalemia and hypomagnesemia before starting. Repeat the ECG if other QT-prolonging drugs are added or if palpitations or syncope occur.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
