Drug interactions
Armodafinil + Elbasvir / grazoprevir
Severity: Major
Armodafinil and Elbasvir / grazoprevir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moderate CYP3A inducers can lower elbasvir and grazoprevir concentrations, risking reduced antiviral activity and virologic failure in hepatitis C treatment. Labeling advises avoiding such inducers.
What this interaction means in plain words
Armodafinil and Elbasvir / grazoprevir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Armodafinil induces CYP3A4, increasing the metabolism of both elbasvir and grazoprevir.
What to do
Avoid the combination during the hepatitis C treatment course and use a non-inducing alternative to armodafinil. Monitor HCV RNA response if unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Elbasvir / grazoprevir?
MediHelp rates the interaction as major. Armodafinil and Elbasvir / grazoprevir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Moderate CYP3A inducers can lower elbasvir and grazoprevir concentrations, risking reduced antiviral activity and virologic failure in hepatitis C treatment. Labeling advises avoiding such inducers.
How serious is the interaction between Armodafinil and Elbasvir / grazoprevir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination during the hepatitis C treatment course and use a non-inducing alternative to armodafinil. Monitor HCV RNA response if unavoidable.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Cyclosporine, Elacestrant. The full list is on the Armodafinil page.
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