Drug interactions
Armodafinil + Ethinylestradiol
Severity: Major
Armodafinil and Ethinylestradiol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil can lower ethinylestradiol exposure and may reduce the effectiveness of hormonal contraceptives, with a risk of unintended pregnancy. This effect may persist for about a month after armodafinil is stopped.
What this interaction means in plain words
Armodafinil and Ethinylestradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Armodafinil induces CYP3A4, increasing the metabolism of ethinylestradiol.
What to do
Advise an additional or alternative non-hormonal contraceptive method during armodafinil therapy and for one month after stopping it.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Ethinylestradiol?
MediHelp rates the interaction as major. Armodafinil and Ethinylestradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Armodafinil can lower ethinylestradiol exposure and may reduce the effectiveness of hormonal contraceptives, with a risk of unintended pregnancy. This effect may persist for about a month after armodafinil is stopped.
How serious is the interaction between Armodafinil and Ethinylestradiol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional or alternative non-hormonal contraceptive method during armodafinil therapy and for one month after stopping it.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Cyclosporine, Elacestrant. The full list is on the Armodafinil page.
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