Drug interactions
Artemether + Dasatinib
Severity: Major
Artemether and Dasatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib and artemether (usually given with lumefantrine) can each prolong the QT interval. Together they may increase the chance of clinically significant arrhythmia, and artemether may also modestly affect CYP3A4 activity.
What this interaction means in plain words
Artemether and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation; artemether-lumefantrine is also a CYP3A4 substrate with possible interaction effects.
What to do
Prefer an antimalarial without QT liability while dasatinib is being taken. If both are required, record a baseline ECG, correct electrolytes and monitor the QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Artemether with Dasatinib?
MediHelp rates the interaction as major. Artemether and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dasatinib and artemether (usually given with lumefantrine) can each prolong the QT interval. Together they may increase the chance of clinically significant arrhythmia, and artemether may also modestly affect CYP3A4 activity.
How serious is the interaction between Artemether and Dasatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antimalarial without QT liability while dasatinib is being taken. If both are required, record a baseline ECG, correct electrolytes and monitor the QTc.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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