Drug interactions
Artemether + Haloperidol
Severity: Major
Artemether and Haloperidol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether (given with lumefantrine) and haloperidol can each prolong the QT interval, so combined use may increase the risk of torsades de pointes. Risk is higher with electrolyte disturbances or other QT-prolonging drugs.
What this interaction means in plain words
Artemether and Haloperidol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive prolongation of cardiac repolarization (QT interval).
What to do
Avoid the combination if possible, or obtain an ECG and correct potassium and magnesium before and during treatment. Consider an alternative antimalarial or antipsychotic where feasible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Artemether with Haloperidol?
MediHelp rates the interaction as major. Artemether and Haloperidol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Artemether (given with lumefantrine) and haloperidol can each prolong the QT interval, so combined use may increase the risk of torsades de pointes. Risk is higher with electrolyte disturbances or other QT-prolonging drugs.
How serious is the interaction between Artemether and Haloperidol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or obtain an ECG and correct potassium and magnesium before and during treatment. Consider an alternative antimalarial or antipsychotic where feasible.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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