Drug interactions
Haloperidol + Ibutilide
Severity: Contraindicated
Haloperidol and Ibutilide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibutilide causes marked QT prolongation and torsades de pointes, and haloperidol adds to this effect. The combination raises the risk of life-threatening arrhythmia.
What this interaction means in plain words
Haloperidol and Ibutilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Haloperidol belongs to Central Nervous System; Ibutilide belongs to Cardiovascular.
Why it happens
Additive blockade of repolarizing potassium currents causing QT prolongation.
What to do
Avoid ibutilide in patients taking haloperidol; consider electrical cardioversion or another antiarrhythmic strategy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Haloperidol and Ibutilide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
- Haloperidol + Ziprasidone Contraindicated
Other interactions of Ibutilide
- Amiodarone + Ibutilide Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Clarithromycin + Ibutilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Dolasetron + Ibutilide Contraindicated
Frequently asked questions
Can I take Haloperidol with Ibutilide?
MediHelp rates the interaction as contraindicated. Haloperidol and Ibutilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ibutilide causes marked QT prolongation and torsades de pointes, and haloperidol adds to this effect. The combination raises the risk of life-threatening arrhythmia.
How serious is the interaction between Haloperidol and Ibutilide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ibutilide in patients taking haloperidol; consider electrical cardioversion or another antiarrhythmic strategy.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Levoketoconazole. The full list is on the Haloperidol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
