Drug interactions
Dronedarone + Haloperidol
Severity: Contraindicated
Dronedarone and Haloperidol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong QT, and haloperidol has well-documented torsades de pointes reports, particularly at higher doses or intravenously. Dronedarone labeling contraindicates use with drugs that prolong QT and may cause torsades de pointes.
What this interaction means in plain words
Dronedarone and Haloperidol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dronedarone belongs to Cardiovascular; Haloperidol belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Do not co-administer; choose an antipsychotic with lower QT liability or another antiarrhythmic strategy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
- Haloperidol + Ziprasidone Contraindicated
Frequently asked questions
Can I take Dronedarone with Haloperidol?
MediHelp rates the interaction as contraindicated. Dronedarone and Haloperidol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents can prolong QT, and haloperidol has well-documented torsades de pointes reports, particularly at higher doses or intravenously. Dronedarone labeling contraindicates use with drugs that prolong QT and may cause torsades de pointes.
How serious is the interaction between Dronedarone and Haloperidol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; choose an antipsychotic with lower QT liability or another antiarrhythmic strategy.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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