Drug interactions
Haloperidol + Levoketoconazole
Severity: Contraindicated
Haloperidol and Levoketoconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole prolongs the QT interval and strongly inhibits CYP3A4, which can raise haloperidol levels. The combination markedly increases the risk of torsades de pointes.
What this interaction means in plain words
Haloperidol and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Haloperidol belongs to Central Nervous System; Levoketoconazole belongs to Endocrine.
Why it happens
Additive QT prolongation with strong CYP3A4 inhibition increasing haloperidol exposure.
What to do
Avoid the combination and select a non-QT-prolonging antipsychotic. If unavoidable, monitor the ECG and electrolytes closely.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
- Haloperidol + Ziprasidone Contraindicated
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Haloperidol with Levoketoconazole?
MediHelp rates the interaction as contraindicated. Haloperidol and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole prolongs the QT interval and strongly inhibits CYP3A4, which can raise haloperidol levels. The combination markedly increases the risk of torsades de pointes.
How serious is the interaction between Haloperidol and Levoketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and select a non-QT-prolonging antipsychotic. If unavoidable, monitor the ECG and electrolytes closely.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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