Drug interactions
Artemether + Paliperidone
Severity: Major
Artemether and Paliperidone: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether, usually given with lumefantrine, can prolong the QT interval. With paliperidone the risk of torsades de pointes is increased.
What this interaction means in plain words
Artemether and Paliperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Avoid if possible and consider an antimalarial with less QT effect. If it must be used, obtain an ECG and correct electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Invega 3 mg prolonged-release tablets - SmPC sections 4.3/4.5 (class statement: some antimalarials; "some other antipsychotics and some antimalarials (e.g., mefloquine).") — electronic medicines compendium (UK SmPC)
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Artemether with Paliperidone?
MediHelp rates the interaction as major. Artemether and Paliperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Artemether, usually given with lumefantrine, can prolong the QT interval. With paliperidone the risk of torsades de pointes is increased.
How serious is the interaction between Artemether and Paliperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and consider an antimalarial with less QT effect. If it must be used, obtain an ECG and correct electrolytes.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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