Drug interactions
Artemether / lumefantrine + Cinacalcet
Severity: Minor
Artemether / lumefantrine and Cinacalcet: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether is a weak CYP3A4 inducer and lumefantrine is metabolized by CYP3A4, but cinacalcet is cleared by several enzymes including CYP3A4, CYP2D6 and CYP1A2. Reduced cinacalcet exposure is possible but expected to be small during a short antimalarial course. Lumefantrine can inhibit CYP2D6, which may slightly raise cinacalcet.
What this interaction means in plain words
Artemether / lumefantrine and Cinacalcet have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible modest CYP3A4 induction by artemether lowering cinacalcet exposure, with potential CYP2D6 effects of lumefantrine.
What to do
Monitor serum calcium and PTH if the combination is used. No empiric dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Artemether / lumefantrine with Cinacalcet?
MediHelp rates the interaction as minor. Artemether / lumefantrine and Cinacalcet have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artemether is a weak CYP3A4 inducer and lumefantrine is metabolized by CYP3A4, but cinacalcet is cleared by several enzymes including CYP3A4, CYP2D6 and CYP1A2. Reduced cinacalcet exposure is possible but expected to be small during a short antimalarial course. Lumefantrine can inhibit CYP2D6, which may slightly raise cinacalcet.
How serious is the interaction between Artemether / lumefantrine and Cinacalcet?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and PTH if the combination is used. No empiric dose change is needed.
What other medicines interact with Cinacalcet?
MediHelp also lists interactions of Cinacalcet with, for example, Etelcalcetide, Eliglustat, Metoclopramide. The full list is on the Cinacalcet page.
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