Drug interactions
Cinacalcet + Etelcalcetide
Severity: Contraindicated
Cinacalcet and Etelcalcetide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs activate the calcium-sensing receptor to suppress PTH, and together they can cause severe, life-threatening hypocalcemia. Etelcalcetide labeling advises against concomitant use.
What this interaction means in plain words
Cinacalcet and Etelcalcetide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cinacalcet belongs to Miscellaneous; Etelcalcetide belongs to Endocrine.
Why it happens
Additive calcium-sensing receptor agonism causing excessive suppression of PTH and serum calcium.
What to do
Stop cinacalcet at least 7 days before starting etelcalcetide. Monitor serum calcium closely after the switch.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Cinacalcet
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
- Amobarbital + Cinacalcet Moderate
Other interactions of Etelcalcetide
- Calcium + Etelcalcetide Moderate
Frequently asked questions
Can I take Cinacalcet with Etelcalcetide?
MediHelp rates the interaction as contraindicated. Cinacalcet and Etelcalcetide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs activate the calcium-sensing receptor to suppress PTH, and together they can cause severe, life-threatening hypocalcemia. Etelcalcetide labeling advises against concomitant use.
How serious is the interaction between Cinacalcet and Etelcalcetide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop cinacalcet at least 7 days before starting etelcalcetide. Monitor serum calcium closely after the switch.
What other medicines interact with Cinacalcet?
MediHelp also lists interactions of Cinacalcet with, for example, Eliglustat, Metoclopramide, Metoclopramide intranasal. The full list is on the Cinacalcet page.
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