Drug interactions
Cinacalcet + Metoclopramide
Severity: Major
Cinacalcet and Metoclopramide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinacalcet is a strong CYP2D6 inhibitor and can raise metoclopramide exposure, since CYP2D6 is its main metabolic route. Higher levels increase the risk of extrapyramidal symptoms, tardive dyskinesia and sedation.
What this interaction means in plain words
Cinacalcet and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cinacalcet belongs to Miscellaneous; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Inhibition of CYP2D6-mediated metabolism of metoclopramide by cinacalcet.
What to do
Reduce the metoclopramide dose in line with labeling for strong CYP2D6 inhibitors, or choose an alternative antiemetic or prokinetic. Monitor for movement disorders, restlessness and drowsiness.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Metoclopramide
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
- Amobarbital + Cinacalcet Moderate
Frequently asked questions
Can I take Cinacalcet with Metoclopramide?
MediHelp rates the interaction as major. Cinacalcet and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cinacalcet is a strong CYP2D6 inhibitor and can raise metoclopramide exposure, since CYP2D6 is its main metabolic route. Higher levels increase the risk of extrapyramidal symptoms, tardive dyskinesia and sedation.
How serious is the interaction between Cinacalcet and Metoclopramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the metoclopramide dose in line with labeling for strong CYP2D6 inhibitors, or choose an alternative antiemetic or prokinetic. Monitor for movement disorders, restlessness and drowsiness.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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