Drug interactions
Cinacalcet + Eliglustat
Severity: Major
Cinacalcet and Eliglustat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinacalcet is a strong CYP2D6 inhibitor and eliglustat is mainly cleared by CYP2D6. Eliglustat exposure rises, increasing the risk of PR, QRS and QT prolongation.
What this interaction means in plain words
Cinacalcet and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cinacalcet belongs to Miscellaneous; Eliglustat belongs to Miscellaneous.
Why it happens
Inhibition of CYP2D6-mediated eliglustat metabolism by cinacalcet.
What to do
Reduce eliglustat dose per labeling for use with CYP2D6 inhibitors and monitor ECG. Avoid if a CYP3A inhibitor is also being taken.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
- Amobarbital + Cinacalcet Moderate
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Cinacalcet with Eliglustat?
MediHelp rates the interaction as major. Cinacalcet and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cinacalcet is a strong CYP2D6 inhibitor and eliglustat is mainly cleared by CYP2D6. Eliglustat exposure rises, increasing the risk of PR, QRS and QT prolongation.
How serious is the interaction between Cinacalcet and Eliglustat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce eliglustat dose per labeling for use with CYP2D6 inhibitors and monitor ECG. Avoid if a CYP3A inhibitor is also being taken.
What other medicines interact with Cinacalcet?
MediHelp also lists interactions of Cinacalcet with, for example, Etelcalcetide, Metoclopramide, Metoclopramide intranasal. The full list is on the Cinacalcet page.
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