Drug interactions
Artemether / lumefantrine + Dapsone
Severity: Minor
Artemether / lumefantrine and Dapsone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether has weak CYP3A4 inducing activity, which could slightly lower dapsone levels. The effect is likely small and short-lived given the brief antimalarial course.
What this interaction means in plain words
Artemether / lumefantrine and Dapsone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Artemether weakly induces CYP3A4, modestly increasing dapsone metabolism.
What to do
No dose change is generally required. Monitor clinical response to dapsone during and after the course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Frequently asked questions
Can I take Artemether / lumefantrine with Dapsone?
MediHelp rates the interaction as minor. Artemether / lumefantrine and Dapsone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artemether has weak CYP3A4 inducing activity, which could slightly lower dapsone levels. The effect is likely small and short-lived given the brief antimalarial course.
How serious is the interaction between Artemether / lumefantrine and Dapsone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required. Monitor clinical response to dapsone during and after the course.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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