Drug interactions
Apalutamide + Dapsone
Severity: Moderate
Apalutamide and Dapsone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong inducer of CYP3A4 and also induces CYP2C19, enzymes involved in dapsone metabolism. Dapsone concentrations may fall, which could reduce efficacy. Induction may also increase formation of hydroxylamine metabolites linked to methemoglobinemia and hemolysis.
What this interaction means in plain words
Apalutamide and Dapsone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Dapsone belongs to Anti Bacterial.
Why it happens
Apalutamide induces CYP3A4 (and CYP2C19), increasing dapsone clearance and possibly altering metabolite formation.
What to do
Monitor for loss of dapsone efficacy and for methemoglobinemia or hemolysis with blood counts. Consider an alternative agent if efficacy cannot be assured.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
- Carbamazepine + Dapsone Moderate
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Dapsone?
MediHelp rates the interaction as moderate. Apalutamide and Dapsone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong inducer of CYP3A4 and also induces CYP2C19, enzymes involved in dapsone metabolism. Dapsone concentrations may fall, which could reduce efficacy. Induction may also increase formation of hydroxylamine metabolites linked to methemoglobinemia and hemolysis.
How serious is the interaction between Apalutamide and Dapsone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of dapsone efficacy and for methemoglobinemia or hemolysis with blood counts. Consider an alternative agent if efficacy cannot be assured.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Belzutifan. The full list is on the Dapsone page.
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