Drug interactions
Belzutifan + Dapsone
Severity: Moderate
Belzutifan and Dapsone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan induces CYP3A4 and may lower exposure to CYP3A4 substrates, which could reduce dapsone concentrations. Dapsone is metabolized by several pathways, so the effect is probably modest.
What this interaction means in plain words
Belzutifan and Dapsone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belzutifan belongs to Miscellaneous; Dapsone belongs to Anti Bacterial.
Why it happens
Belzutifan induces CYP3A4, increasing metabolism of dapsone.
What to do
Monitor for reduced dapsone efficacy and consider dose adjustment if response is inadequate. Also monitor hemoglobin, as belzutifan causes anemia and dapsone causes hemolysis and methemoglobinemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
- Carbamazepine + Dapsone Moderate
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Dapsone?
MediHelp rates the interaction as moderate. Belzutifan and Dapsone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belzutifan induces CYP3A4 and may lower exposure to CYP3A4 substrates, which could reduce dapsone concentrations. Dapsone is metabolized by several pathways, so the effect is probably modest.
How serious is the interaction between Belzutifan and Dapsone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced dapsone efficacy and consider dose adjustment if response is inadequate. Also monitor hemoglobin, as belzutifan causes anemia and dapsone causes hemolysis and methemoglobinemia.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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