Drug interactions
Artemether / lumefantrine + Eplerenone
Severity: Minor
Artemether / lumefantrine and Eplerenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether can induce CYP3A4 on repeated dosing, whereas lumefantrine and artemether are themselves CYP3A4 substrates. Eplerenone exposure may be reduced during a treatment course, though the effect is likely short-lived.
What this interaction means in plain words
Artemether / lumefantrine and Eplerenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP3A4 induction by artemether increasing eplerenone metabolism.
What to do
Monitor blood pressure during and shortly after the antimalarial course. No empirical dose change is generally needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Artemether / lumefantrine with Eplerenone?
MediHelp rates the interaction as minor. Artemether / lumefantrine and Eplerenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artemether can induce CYP3A4 on repeated dosing, whereas lumefantrine and artemether are themselves CYP3A4 substrates. Eplerenone exposure may be reduced during a treatment course, though the effect is likely short-lived.
How serious is the interaction between Artemether / lumefantrine and Eplerenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during and shortly after the antimalarial course. No empirical dose change is generally needed.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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