Drug interactions
Artemether / lumefantrine + Fluphenazine
Severity: Major
Artemether / lumefantrine and Fluphenazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether/lumefantrine can prolong the QT interval and fluphenazine has similar effects, so combined use increases arrhythmia risk. Labeling advises against combining it with other QT-prolonging drugs.
What this interaction means in plain words
Artemether / lumefantrine and Fluphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation.
What to do
Avoid the combination; consider an alternative antimalarial or delay fluphenazine if possible. If unavoidable, obtain an ECG and correct electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Artemether / lumefantrine with Fluphenazine?
MediHelp rates the interaction as major. Artemether / lumefantrine and Fluphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Artemether/lumefantrine can prolong the QT interval and fluphenazine has similar effects, so combined use increases arrhythmia risk. Labeling advises against combining it with other QT-prolonging drugs.
How serious is the interaction between Artemether / lumefantrine and Fluphenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; consider an alternative antimalarial or delay fluphenazine if possible. If unavoidable, obtain an ECG and correct electrolytes.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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