Drug interactions
Fluphenazine + Ibutilide
Severity: Contraindicated
Fluphenazine and Ibutilide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibutilide causes marked QT prolongation and torsades de pointes, and phenothiazines add to this effect. The combination heightens the risk of life-threatening arrhythmia.
What this interaction means in plain words
Fluphenazine and Ibutilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluphenazine belongs to Central Nervous System; Ibutilide belongs to Cardiovascular.
Why it happens
Additive blockade of repolarizing potassium currents causing QT prolongation.
What to do
Avoid giving ibutilide to patients taking fluphenazine; consider electrical cardioversion or another strategy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
- Amiodarone + Fluphenazine Major
Other interactions of Ibutilide
- Amiodarone + Ibutilide Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Clarithromycin + Ibutilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Dolasetron + Ibutilide Contraindicated
Frequently asked questions
Can I take Fluphenazine with Ibutilide?
MediHelp rates the interaction as contraindicated. Fluphenazine and Ibutilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ibutilide causes marked QT prolongation and torsades de pointes, and phenothiazines add to this effect. The combination heightens the risk of life-threatening arrhythmia.
How serious is the interaction between Fluphenazine and Ibutilide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving ibutilide to patients taking fluphenazine; consider electrical cardioversion or another strategy.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Pimozide. The full list is on the Fluphenazine page.
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