Drug interactions
Arsenic trioxide + Fluphenazine
Severity: Contraindicated
Arsenic trioxide and Fluphenazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Arsenic trioxide causes marked QT prolongation and torsades de pointes, and fluphenazine adds further QT risk. Labeling advises avoiding other QT-prolonging drugs.
What this interaction means in plain words
Arsenic trioxide and Fluphenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Arsenic trioxide belongs to Oncology; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid concurrent use and choose a non-QT-prolonging antipsychotic. Keep potassium and magnesium normal and monitor ECG throughout arsenic therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Arsenic trioxide and Fluphenazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Fluphenazine
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
- Amiodarone + Fluphenazine Major
Other interactions of Arsenic trioxide
- Amiodarone + Arsenic trioxide Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Arsenic trioxide + Clomipramine Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Arsenic trioxide + Gemifloxacin Contraindicated
- Arsenic trioxide + Hydroxychloroquine Contraindicated
Frequently asked questions
Can I take Arsenic trioxide with Fluphenazine?
MediHelp rates the interaction as contraindicated. Arsenic trioxide and Fluphenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Arsenic trioxide causes marked QT prolongation and torsades de pointes, and fluphenazine adds further QT risk. Labeling advises avoiding other QT-prolonging drugs.
How serious is the interaction between Arsenic trioxide and Fluphenazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a non-QT-prolonging antipsychotic. Keep potassium and magnesium normal and monitor ECG throughout arsenic therapy.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Fluphenazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
