Drug interactions
Artemether / lumefantrine + Indacaterol-glycopyrronium
Severity: Moderate
Artemether / lumefantrine and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether-lumefantrine can prolong the QT interval, and indacaterol can contribute to repolarization changes and hypokalemia. The combination may increase the risk of torsade de pointes, especially with electrolyte disturbance or heart disease.
What this interaction means in plain words
Artemether / lumefantrine and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and beta2-agonist related hypokalemia.
What to do
Correct potassium and magnesium abnormalities and consider an ECG in patients with cardiac risk factors. Monitor for arrhythmia symptoms during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Frequently asked questions
Can I take Artemether / lumefantrine with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Artemether / lumefantrine and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Artemether-lumefantrine can prolong the QT interval, and indacaterol can contribute to repolarization changes and hypokalemia. The combination may increase the risk of torsade de pointes, especially with electrolyte disturbance or heart disease.
How serious is the interaction between Artemether / lumefantrine and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium abnormalities and consider an ECG in patients with cardiac risk factors. Monitor for arrhythmia symptoms during treatment.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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