Drug interactions
Artemether / lumefantrine + Liposomal doxorubicin
Severity: Minor
Artemether / lumefantrine and Liposomal doxorubicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether can weakly induce CYP3A4, but doxorubicin depends little on this enzyme. No meaningful loss of doxorubicin effect is expected. Both drugs can affect cardiac conduction or cardiac function, so awareness of this is reasonable.
What this interaction means in plain words
Artemether / lumefantrine and Liposomal doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 induction by artemether, with minimal relevance to doxorubicin clearance.
What to do
No dose adjustment is needed. Consider an ECG if QT-prolonging drugs are also given.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Frequently asked questions
Can I take Artemether / lumefantrine with Liposomal doxorubicin?
MediHelp rates the interaction as minor. Artemether / lumefantrine and Liposomal doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artemether can weakly induce CYP3A4, but doxorubicin depends little on this enzyme. No meaningful loss of doxorubicin effect is expected. Both drugs can affect cardiac conduction or cardiac function, so awareness of this is reasonable.
How serious is the interaction between Artemether / lumefantrine and Liposomal doxorubicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Consider an ECG if QT-prolonging drugs are also given.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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