Drug interactions
Artemether / lumefantrine + Metoprolol
Severity: Moderate
Artemether / lumefantrine and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine is a CYP2D6 inhibitor and may raise metoprolol levels, increasing bradycardia and hypotension. Both lumefantrine and artemether-lumefantrine labeling advise caution with CYP2D6 substrates, and the combination also involves QT-related concerns.
What this interaction means in plain words
Artemether / lumefantrine and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2D6-mediated metoprolol metabolism by lumefantrine.
What to do
Monitor heart rate and blood pressure and reduce the metoprolol dose if bradycardia or hypotension occurs. Consider an ECG given the QT effects of the antimalarial.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Artemether / lumefantrine with Metoprolol?
MediHelp rates the interaction as moderate. Artemether / lumefantrine and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumefantrine is a CYP2D6 inhibitor and may raise metoprolol levels, increasing bradycardia and hypotension. Both lumefantrine and artemether-lumefantrine labeling advise caution with CYP2D6 substrates, and the combination also involves QT-related concerns.
How serious is the interaction between Artemether / lumefantrine and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and reduce the metoprolol dose if bradycardia or hypotension occurs. Consider an ECG given the QT effects of the antimalarial.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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