Drug interactions
Artemether / lumefantrine + Oxaliplatin
Severity: Moderate
Artemether / lumefantrine and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether-lumefantrine can prolong the QT interval, and oxaliplatin has also been linked to QT prolongation. Combined use may increase the risk of torsades de pointes, particularly if electrolytes are low.
What this interaction means in plain words
Artemether / lumefantrine and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain a baseline ECG and correct hypokalemia and hypomagnesemia. Treat malaria promptly, as it is potentially fatal, and monitor ECG during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Artemether / lumefantrine with Oxaliplatin?
MediHelp rates the interaction as moderate. Artemether / lumefantrine and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Artemether-lumefantrine can prolong the QT interval, and oxaliplatin has also been linked to QT prolongation. Combined use may increase the risk of torsades de pointes, particularly if electrolytes are low.
How serious is the interaction between Artemether / lumefantrine and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct hypokalemia and hypomagnesemia. Treat malaria promptly, as it is potentially fatal, and monitor ECG during therapy.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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