Drug interactions
Artemether / lumefantrine + Sirolimus
Severity: Moderate
Artemether / lumefantrine and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether/lumefantrine may lower sirolimus concentrations through CYP3A4 induction by artemether. Reduced levels could increase the risk of rejection. Lumefantrine also prolongs the QT interval, but this is not a pharmacokinetic effect on sirolimus.
What this interaction means in plain words
Artemether / lumefantrine and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Artemether may induce CYP3A4, increasing sirolimus metabolism, but the effect is modest and short-lived with a 3-day course.
What to do
Monitor sirolimus trough levels during and after the antimalarial course and adjust the dose as needed. Treat malaria without delay since the effect is short term.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Artemether / lumefantrine with Sirolimus?
MediHelp rates the interaction as moderate. Artemether / lumefantrine and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Artemether/lumefantrine may lower sirolimus concentrations through CYP3A4 induction by artemether. Reduced levels could increase the risk of rejection. Lumefantrine also prolongs the QT interval, but this is not a pharmacokinetic effect on sirolimus.
How serious is the interaction between Artemether / lumefantrine and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough levels during and after the antimalarial course and adjust the dose as needed. Treat malaria without delay since the effect is short term.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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