Drug interactions
Artemether / lumefantrine + Solifenacin
Severity: Moderate
Artemether / lumefantrine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether/lumefantrine prolongs the QT interval, and solifenacin may add to this effect. Risk is higher with electrolyte disturbance, bradycardia, or other QT-prolonging drugs.
What this interaction means in plain words
Artemether / lumefantrine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation; lumefantrine has a long half-life so the effect persists.
What to do
Hold solifenacin during the antimalarial course if possible, or obtain an ECG and correct electrolytes before and during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Frequently asked questions
Can I take Artemether / lumefantrine with Solifenacin?
MediHelp rates the interaction as moderate. Artemether / lumefantrine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Artemether/lumefantrine prolongs the QT interval, and solifenacin may add to this effect. Risk is higher with electrolyte disturbance, bradycardia, or other QT-prolonging drugs.
How serious is the interaction between Artemether / lumefantrine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold solifenacin during the antimalarial course if possible, or obtain an ECG and correct electrolytes before and during treatment.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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