Drug interactions
Anagrelide + Solifenacin
Severity: Major
Anagrelide and Solifenacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so co-use may increase the risk of ventricular arrhythmias such as torsades de pointes. Anagrelide can also cause tachycardia and palpitations.
What this interaction means in plain words
Anagrelide and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT prolongation through pharmacodynamic effects.
What to do
Avoid if possible or obtain a baseline ECG and monitor it, keeping potassium and magnesium within normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Solifenacin
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Solifenacin?
MediHelp rates the interaction as major. Anagrelide and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so co-use may increase the risk of ventricular arrhythmias such as torsades de pointes. Anagrelide can also cause tachycardia and palpitations.
How serious is the interaction between Anagrelide and Solifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible or obtain a baseline ECG and monitor it, keeping potassium and magnesium within normal range.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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