Drug interactions
Bedaquiline + Solifenacin
Severity: Major
Bedaquiline and Solifenacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and combining them may increase the risk of torsades de pointes. The risk rises with electrolyte disturbances, bradycardia, heart disease or additional QT-prolonging drugs.
What this interaction means in plain words
Bedaquiline and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bedaquiline belongs to Anti Bacterial; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT prolongation through cardiac repolarization effects.
What to do
Obtain a baseline ECG and monitor it periodically, and correct potassium, magnesium and calcium; consider an alternative to solifenacin if QTc becomes prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Solifenacin
Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amiodarone + Bedaquiline Major
- Amisulpride + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Amobarbital + Bedaquiline Major
Frequently asked questions
Can I take Bedaquiline with Solifenacin?
MediHelp rates the interaction as major. Bedaquiline and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and combining them may increase the risk of torsades de pointes. The risk rises with electrolyte disturbances, bradycardia, heart disease or additional QT-prolonging drugs.
How serious is the interaction between Bedaquiline and Solifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it periodically, and correct potassium, magnesium and calcium; consider an alternative to solifenacin if QTc becomes prolonged.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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