Drug interactions
Artemether / lumefantrine + Sotalol
Severity: Contraindicated
Artemether / lumefantrine and Sotalol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both sotalol and lumefantrine prolong the QT interval, and the combination raises the risk of torsades de pointes. Artemether/lumefantrine labeling advises avoiding use with other QT-prolonging drugs.
What this interaction means in plain words
Artemether / lumefantrine and Sotalol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive QT prolongation from sotalol potassium channel blockade and lumefantrine.
What to do
Avoid co-use; select an alternative antimalarial or temporarily alternative antiarrhythmic therapy, and monitor ECG if unavoidable.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
- Eliglustat + Sotalol Contraindicated
Frequently asked questions
Can I take Artemether / lumefantrine with Sotalol?
MediHelp rates the interaction as contraindicated. Artemether / lumefantrine and Sotalol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both sotalol and lumefantrine prolong the QT interval, and the combination raises the risk of torsades de pointes. Artemether/lumefantrine labeling advises avoiding use with other QT-prolonging drugs.
How serious is the interaction between Artemether / lumefantrine and Sotalol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid co-use; select an alternative antimalarial or temporarily alternative antiarrhythmic therapy, and monitor ECG if unavoidable.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Sotalol page.
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