Drug reference
sotalol
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Anti Arrhythmia)
Mechanism of action
Antiarrhythmic: Class II (beta blockade) and class III (action potential prolongation) properties, Has adrenoceptor-blocking effect and markedly prolongs action potential and repolarization
Common side effects
- Dizziness
- Fatigue
- Dyspnea
- Bradycardia
- Chest pain
- Palpitation
Boxed warnings
- Minimize risk of drug-induced arrhythmia by initiating or uptitrating IV or PO sotalol in a facility that can provide continuous ECG monitoring and cardiac resuscitation Calculate CrCl before initiating sotalol therapy; adjust dosing interval based on creatinine clearance Sotalol has proarrhythmic effects and can cause life-threatening ventricular tachycardia associated with QT interval prolongation; do not initiate therapy if baseline QTc is >450 msec; if QT interval prolongs to ≥500 msec, dose must be reduced, duration of infusion prolonged or drug discontinued
Contraindications
- Sinus bradycardia (<50 bpm), sick sinus syndrome or second or third degree AV block without a pacemaker Congenital or acquired long QT syndromes, QT interval >450 ms Cardiogenic shock, decompensated heart failure Serum potassium <4 mEq/L Bronchial asthma or related bronchospastic condit…
Known interactions (15)
- dronedarone + sotalol Contraindicated
- fingolimod + sotalol Contraindicated
- adrenaline-articaine + sotalol Major
- amitriptyline + sotalol Major
- chlorpromazine + sotalol Major
- clomipramine + sotalol Major
- desipramine + sotalol Major
- epinephrine + sotalol Major
- erythromycin + sotalol Major
- fluphenazine + sotalol Major
- goserelin + sotalol Major
- haloperidol + sotalol Major
- imipramine + sotalol Major
- indapamide + sotalol Major
- moxifloxacin + sotalol Major
Related conditions
Frequently asked questions
What drug class is sotalol?
sotalol belongs to: Cardiovascular.
How does sotalol work?
Antiarrhythmic: Class II (beta blockade) and class III (action potential prolongation) properties, Has adrenoceptor-blocking effect and markedly prolongs action potential and repolarization
What are the common side effects of sotalol?
Dizziness, Fatigue, Dyspnea, Bradycardia, Chest pain, Palpitation
Which drugs interact with sotalol?
dronedarone, fingolimod, adrenaline-articaine, amitriptyline, chlorpromazine, clomipramine, desipramine, epinephrine, erythromycin, fluphenazine, goserelin, haloperidol, imipramine, indapamide, moxifloxacin
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.