Drug interactions
Dofetilide + Sotalol
Severity: Contraindicated
Dofetilide and Sotalol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are class III antiarrhythmics that block cardiac potassium channels and prolong the QT interval. Together they markedly increase the risk of torsades de pointes.
What this interaction means in plain words
Dofetilide and Sotalol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dofetilide belongs to Cardiovascular; Sotalol belongs to Cardiovascular.
Why it happens
Additive blockade of the delayed rectifier potassium current causing QT prolongation.
What to do
Do not use together; allow adequate washout of one agent before starting the other with ECG monitoring in a supervised setting.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
- Eliglustat + Sotalol Contraindicated
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Sotalol?
MediHelp rates the interaction as contraindicated. Dofetilide and Sotalol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are class III antiarrhythmics that block cardiac potassium channels and prolong the QT interval. Together they markedly increase the risk of torsades de pointes.
How serious is the interaction between Dofetilide and Sotalol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; allow adequate washout of one agent before starting the other with ECG monitoring in a supervised setting.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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