Drug interactions
Arsenic trioxide + Sotalol
Severity: Contraindicated
Arsenic trioxide and Sotalol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Arsenic trioxide causes marked QT prolongation and torsades de pointes. Adding sotalol greatly increases the arrhythmia risk.
What this interaction means in plain words
Arsenic trioxide and Sotalol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Arsenic trioxide belongs to Oncology; Sotalol belongs to Cardiovascular.
Why it happens
Additive QT prolongation.
What to do
Avoid the combination and use an alternative to sotalol. Monitor ECG and keep potassium and magnesium within range during arsenic therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Sotalol
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
- Eliglustat + Sotalol Contraindicated
Other interactions of Arsenic trioxide
- Amiodarone + Arsenic trioxide Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Arsenic trioxide + Clomipramine Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Arsenic trioxide + Fluphenazine Contraindicated
- Arsenic trioxide + Gemifloxacin Contraindicated
Frequently asked questions
Can I take Arsenic trioxide with Sotalol?
MediHelp rates the interaction as contraindicated. Arsenic trioxide and Sotalol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Arsenic trioxide causes marked QT prolongation and torsades de pointes. Adding sotalol greatly increases the arrhythmia risk.
How serious is the interaction between Arsenic trioxide and Sotalol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative to sotalol. Monitor ECG and keep potassium and magnesium within range during arsenic therapy.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Artemether / lumefantrine, Disopyramide, Dofetilide. The full list is on the Sotalol page.
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